![]() ![]() The Charles River " hairless" rat mutation is distinct from the hairless mouse alleles. The Charles River (CR) " hairless" rat is one of the autosomal recessive hypotrichotic animal models actively studied in pharmacologic and dermatologic research. Despite its widespread use, the molecular basis of this monogenic mutation remains unknown, and the skin histologic features of this phenotype have never been described. However, the designation " hairless" has been used as an extension of the hairless mouse (hr) nomenclature on the basis of the clinical absence of hairs in both phenotypes. We present a description of the histopathologic changes in heterozygous and homozygous CR hairless rat mutants during the first month of life. The postnatal homozygous rat skin was characterized by abnormal keratinization of the hair shaft and formation of a thick and dense layer of corneocytes in the lower portion of the epidermal stratum corneum. This layer prevented the improperly keratinized hair shaft from penetrating the skin surface. Starting from the latest stages of hair follicle (HF) development, obvious signs of HF degeneration were observed in homozygous skin. ![]() This process was extremely rapid, and by day 12, mainly atrophic HFs with abnormal or broken hairs were present in the skin. Therefore, the mutation in the CR rat abrogates cell proliferation in the hair matrix and affects keratinocyte differentiation in the HF and interfollicular epidermis, a phenotype that is completely distinct from hr/hr. ![]() However, following revelations that some of the images may constitute child pornography, a moderator has warned that any images featuring Maroney or Lee "will be immediately removed".To test whether the CR rat harbored a mutation in the hr gene, we analyzed the coding region of this gene and consensus intron splice site sequences in mutant rats and found no mutation, further supporting phenotypic evidence that the hairless phenotype in CR rats is not allelic with hairless. The hacked photographs were originally thought to have been posted on a "deep web" forum a week ago, but it was only when the images were subsequently uploaded to the 4chan anonymous image-sharing forum on Sunday that they were circulated widely.Īccording to online news organisation The Daily Dot, the Reddit community r/TheFappening has become the main hub for sharing the stolen photographs, because Reddit is one of the few mainstream websites that is not deleting links to the photos. The images so far released online are believed to represent only a fraction of a vast archive of explicit photographs that a group of hackers has been amassing for months, possibly by compromising the stars' iCloud accounts. But her lawyer has reportedly sent a letter to several pornography sites that have reposted the images, demanding that they remove them because Maroney was underage in several of them. Since 1997, we have delivered world-class, locally relevant search and information services. To test whether the CR rat harbored a mutation in the hr gene, we analyzed the coding region of this gene and consensus intron splice site sequences in mutant rats and found no mutation, further supporting phenotypic evidence that the hairless phenotype in CR rats is not allelic with hairless. Our goal is to help consumers and businesses better navigate the online and offline world. Maroney, an Olympic gold medallist and world champion gymnast, tweeted that the photos of her posted online this week were "fake". Yandex is a technology company that builds intelligent products and services powered by machine learning. ![]()
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